For an oocyte to become Completely ready for fertilization and development into an embryo, the best set of genes really should be turned on. Namekawa suspected this pre-programming in the oocyte genome comes about in a number of phases — the first one beginning round the time a female is born. He believed that chromatin remodeling proteins did much of this get the job done, by shifting spools around.
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Work by Namekawa and Munakata indicates that an important party occurs throughout the time of start: the nascent egg cells enter a Keeping sample, with their DNA specifically packaged and primed for fertilization later in everyday life.
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Namekawa believes that in human oocytes, changes in these designs could disrupt the fragile choreography of genes currently being turned on and off at the proper moments — leaving them unprepared for fertilization or growth into nutritious embryos. Adjustments in chromatin composition as an oocyte ages may additionally effects the way in which that chromosomes segregate throughout cell division.
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